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Tuberculosis (TB) is a contagious infection caused mainly by the bacterium Mycobacterium tuberculosis. It most often affects the lungs (pulmonary TB), but it can also affect other parts of the body such as the lymph nodes, bones, kidneys, brain, and spine. pneumonia is an infection of one or both lungs that causes the air sacs (alveoli) to become inflamed and fill with fluid or pus, making breathing difficult.